A Note on the State of Calcium in High Protein Serum.
نویسندگان
چکیده
In the reported experiments of McLean and Hastings, their equation was found to be valid for predicting the calcium ion concentration from the total calcium and total protein when the sera contained 7.5 grams of protein per 100 cc. or less. It has recently been shown by Gutman and Gutman (3) that serum from cases of hyperglobulinemia had less total calcium than one would have expected, if the calcium ion concentrations were normal and if the ionization constant of calcium proteinate (pKca Prt.) had the value which it has in serum of normal protein concentrations. This raises the question as to whether protein which did not have the usual calcium combining power of normal serum albumin and globulin was present, or whether the ionization constant which holds for normal serum is different in high protein serum. The latter question could be answered by determining the value of pKca Prot. in sera whose protein concentration had been increased. This communication presents the results of the determination of pKca Prot. in such sera. EXPERIMENTAL
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ورودعنوان ژورنال:
- The Journal of clinical investigation
دوره 17 2 شماره
صفحات -
تاریخ انتشار 1938